abstract：:This study aimed to investigate the effect of single and repeated administration of fenarimol on murine liver, kidney and lung microsomal CYP-catalyzed drug metabolism. The modulation of the regio- and stereo-selective hydroxylation of testosterone by fenarimol was considered in evaluating cocarcinogenic properties. I...

journal_title：Archives of toxicology

authors： Paolini M,Pozzetti L,Mesirca R,Sapone A,Cantelli-Forti G

更新日期：1996-01-01 00:00:00

abstract：:The effect of culture medium on glutathione (GSH) dependent detoxification defence system of primary cultured hepatocyte from either male or female rats was studied. Intracellular reduced (GSH) and oxidized glutathione (GSSG), and six GSH-related enzyme activities, including GSH peroxidase (GSH Px), GSH reductase (GSH...

journal_title：Archives of toxicology

authors： Lii CK,Wang ST,Chen HW,Sheen LY

更新日期：1996-01-01 00:00:00

abstract：:The reversibility of quinolone-induced cartilage lesions has not been studied in detail. We treated five groups of five to seven juvenile Wistar rats (male and female; age: 5 weeks) with 2 x 600 mg ofloxacin/kg by gastric intubation on 1 day only (9:00 a.m. and 5:00 p.m.) and studied the knee joints histologically 3 d...

journal_title：Archives of toxicology

authors： Förster C,Kociok K,Shakibaei M,Merker HJ,Stahlmann R

更新日期：1996-01-01 00:00:00

abstract：:The influence of pivalic acid (PIV), a compound often used to make pro-drugs, and of the structurally related trichloroacetic acid (TCA), on several hepatic and renal enzymes was investigated in Sprague-Dawley rats, following a 4-day treatment period. The PIV and TCA treatments resulted in a similar and selective indu...

journal_title：Archives of toxicology

authors： Zanelli U,Puccini P,Acerbi D,Ventura P,Gervasi PG

更新日期：1996-01-01 00:00:00

abstract：:Using male ICR mice, the LC50 and acute and subacute inhalation toxicity of dichlorosilane (SiH2Cl2, DCS) and the fate of DCS released into the air were investigated. DCS resolved and minute particles including silicon and chloride were observed, when DCS was released into the air. Most particles were under 1 micron i...

journal_title：Archives of toxicology

authors： Nakashima H,Omae K,Takebayashi T,Ishizuka C,Sakurai H,Yamazaki K,Nakaza M,Shibata T,Kudo M,Koshi S

更新日期：1996-01-01 00:00:00

abstract：:Cadmium (Cd), a highly toxic heavy metal, is distributed widely in the general environment of today. The characteristic clinical manifestations of chronic Cd intoxication include renal proximal tubular dysfunction, general osteomalacia with severe pains, and anemia. We have recently reported that the serum level of er...

journal_title：Archives of toxicology

authors： Horiguchi H,Sato M,Konno N,Fukushima M

更新日期：1996-01-01 00:00:00

abstract：:Di-n-butylin dichloride (DBTCl), which is commonly used as heat and light stabilizer for polyvinyl chloride (PVC) plastics, is a teratogen in vivo. In the present study, the toxic effects were investigated of DBTCl on cultured rat embryos during three different stages of organogenesis. Rat embryos explanted on gestati...

journal_title：Archives of toxicology

authors： Ema M,Iwase T,Iwase Y,Ohyama N,Ogawa Y

更新日期：1996-01-01 00:00:00

abstract：:The consumption of plants containing the diterpenoid atractyloside (ATR) causes selective proximal tubule injury, renal failure and death in humans. We have compared the effects of ATR in freshly isolated renal proximal tubules and glomeruli from rat and also in cell lines: NRK, derived from the proximal tubules, and ...

journal_title：Archives of toxicology

authors： Obatomi DK,Bach PH

更新日期：1996-01-01 00:00:00

abstract：:Quantitative structure-activity relationships (QSAR) have suggested the importance of hydrogen bonding in relation to activation of the sensory irritant receptor by nonreactive volatile organic chemicals. To investigate this possibility further, three model compounds with different hydrogen bond acidity, trifluoroetha...

journal_title：Archives of toxicology

authors： Nielsen GD,Abraham MH,Hansen LF,Hammer M,Cooksey CJ,Andonian-Haftvan J,Alarie Y

更新日期：1996-01-01 00:00:00

abstract：:Renal papillary necrosis (RPN) was induced in Fischer 344 (F344) rats (n = 4) using 2-bromoethanamine hydrobromide (BEA) dosed at 150 mg/kg, and in multimammate desert mice (Mastomys natalensis) at 150 and 250 mg/kg (n = 4 per group). Control rats and Mastomys were dosed with 0.9% saline (n = 4 per group). Urine was c...

journal_title：Archives of toxicology

authors： Holmes E,Bonner FW,Nicholson JK

更新日期：1995-01-01 00:00:00

abstract：:O,O,S-Trimethyl phosphorothioate (OOS-TMP) is known to induce unique symptoms, which are characterized by hypophagia, progressive weight loss, and hypothermia. To determine whether there is the possibility of a causal relationship between these toxic symptoms and a direct action of OOS-TMP on the central nervous syste...

journal_title：Archives of toxicology

authors： Ohtaka K,Hamade N,Yamazaki Y,Suzuki M,Koizumi A

更新日期：1995-01-01 00:00:00

abstract：:The present experiments were performed to test the possibility of interrupting the enterohepatic circulation of arsenic (As). Therefore the efficacy of adsorbents to bind As and/or As-DMPS adducts in vitro and their effect on the excretion of As into the feces and urine in vivo were investigated after injection of As2...

journal_title：Archives of toxicology

authors： Reichl FX,Hunder G,Liebl B,Fichtl B,Forth W

更新日期：1995-01-01 00:00:00

abstract：:Levels of glutathione and activity of glutamine synthetase were assayed in organs of rats following inhalation of a heterogeneous solvent mixture containing both aliphatic and aromatic hydrocarbons. This mixture was administered for 3 weeks (6 h daily) at two levels in the inhaled air (400 and 800 ppm) to young adult ...

journal_title：Archives of toxicology

authors： Bondy SC,Lam HR,Ostergaard G,Guo SX,Ladefoged O

更新日期：1995-01-01 00:00:00

abstract：:Labilization of lysosomal enzymes is often associated with the general process of inflammation. The present study investigated the effect of the pneumotoxin cadmium on the release and activity of two lung lysosomal enzymes. Incubation of rat lung lysosomes with cadmium resulted in the release of beta-glucuronidase but...

journal_title：Archives of toxicology

authors： Giri SN,Hollinger MA

更新日期：1995-01-01 00:00:00

abstract：:The oxidizing capacity of phagocytic cells is suspected to play a major role in the generation of immunogenic drug metabolites, in particular those that cause extrahepatic immunopathological lesions. In the case of the antirheumatic drug gold(I) disodium thiomalate (Na2Au(I)TM), oxidation of the Au(I) ion to Au(III) a...

journal_title：Archives of toxicology

authors： Goebel C,Kubicka-Muranyi M,Tonn T,Gonzalez J,Gleichmann E

更新日期：1995-01-01 00:00:00

abstract：:The mycotoxin ochratoxin A (OTA) and its metabolite ochratoxin alpha (OT-alpha) were investigated, to examine their potency to induce sister chromatid exchanges (SCE) in cultured porcine urinary bladder epithelial cells (PUBEC) (primary culture). Serum-free cultured PUBEC were incubated for 5 h with either OTA or OT-a...

journal_title：Archives of toxicology

authors： Föllmann W,Hillebrand IE,Creppy EE,Bolt HM

更新日期：1995-01-01 00:00:00

abstract：:Bolesatine, a glycoprotein from Boletus satanas Lenz, has previously been shown to be mitogenic to rat and human lymphocytes at very low concentrations, whereas higher concentrations inhibit protein synthesis in vitro and in several in vivo systems. The mechanism whereby this mitogenic activity occurs was previously u...

journal_title：Archives of toxicology

authors： Ennamany R,Kretz O,Creppy EE

更新日期：1995-01-01 00:00:00

abstract：:Monolayers of L6 rat skeletal myoblast cells formed surface binding isotherms with the purified tobacco leaf glycoprotein TGP1 and the enriched cigarette tar glycoprotein TGP2. Scatchard analysis showed that the binding in the range of the limited concentrations tested was to a single class molecule and the calculated...

journal_title：Archives of toxicology

authors： Santos-Buch CA,Hall HR,Farfan F,Orlow I,Firpo A,von Kreuter BF,Becker CG

更新日期：1995-01-01 00:00:00

abstract：:Second order rate constants for the initial reaction of 12 mammalian oxyhemoglobins (Hb) with equimolar phenylhydrazine (PHZ), a compound inducing Heinz body hemolytic anemia, were determined by recording continuous changes in absorbance with time at 577 nm. The rate constants were varied in a range from 43 m-1.s-1 wi...

journal_title：Archives of toxicology

authors： Kinuta M,Matteson JL,Itano HA

更新日期：1995-01-01 00:00:00

abstract：:The effect of methantheline, a quaternary ammonium compound, on the reactivation by HI 6 of soman-inhibited human erythrocyte acetylcholinesterase (AChE) was investigated in vitro using purified human erythrocyte AChE or washed human erythrocytes. Methantheline itself was found to be a mixed competitive/non-competitiv...

journal_title：Archives of toxicology

authors： Hallek M,Szinicz L

更新日期：1995-01-01 00:00:00

abstract：:Milacemide (2-n-pentylaminoacetamide) hydrochloride was administered by continuous i.v. infusion for up to 7 days, at 300 and 600 mg/kg per day to male Sprague-Dawley rats. This was intended to provide high and sustained exposure to evaluate the effect of a preterminal 24-h fast on liver lipid content. Liver lipid con...

journal_title：Archives of toxicology

authors： Rakotoamboa JL,Masson M,Palate B,Carleer J,Roba J

更新日期：1994-01-01 00:00:00

abstract：:The nephrotoxicity of 4-amino-3-S-glutathionylphenol (PAP-GSH), a known metabolite of 4-amino-phenol (PAP), was determined in male Fischer 344 rats. Administration of a single dose of 40 or 60 mumol kg-1 caused a marked elevation in blood urea nitrogen and an increase in the urinary excretion of glucose, protein and g...

journal_title：Archives of toxicology

authors： Fowler LM,Foster JR,Lock EA

更新日期：1994-01-01 00:00:00

abstract：:As previously demonstrated, chronic administration of phenobarbital (0.05% in the drinking water) and of nafenopin (0.1% in the diet) increases the incidence and the kinetics of appearance of liver cancers. If bile acids play a key role in liver carcinogenesis, it might thus be expected that treatments like phenobarbi...

journal_title：Archives of toxicology

authors： Delzenne NM,Taper HS,Roberfroid M

更新日期：1994-01-01 00:00:00

abstract：:Morphological changes in mitochondria are observed early in the course of acetaminophen (AA)-induced hepatotoxicity, and mitochondrial dysfunction has been observed both in vivo and in vitro following exposure to AA. This study examined the early effects of AA exposure in vivo on mitochondrial respiration and evaluate...

journal_title：Archives of toxicology

authors： Donnelly PJ,Walker RM,Racz WJ

更新日期：1994-01-01 00:00:00

abstract：:Rats were exposed to nickel sulfate (NiSO4) either by intratracheal (IT) instillation or by acute aerosol inhalation, and pulmonary clearance of Ni and pulmonary inflammatory responses were studied. The half-time of Ni in the lung (initial lung burden = 50 micrograms Ni/rat) was about 32 h in both the IT instillation ...

journal_title：Archives of toxicology

authors： Hirano S,Shimada T,Osugi J,Kodama N,Suzuki KT

更新日期：1994-01-01 00:00:00

abstract：:Aliphatic nitriles are a class of chemicals used in high volumes in the production of plastics and elastomers, in organic synthesis, and in production of a number of food packaging containers. Toxicity and metabolism of acrylonitrile (AN) are well characterized. On the other hand, minimal information is available on t...

journal_title：Archives of toxicology

authors： Burka LT,Sanchez IM,Ahmed AE,Ghanayem BI

更新日期：1994-01-01 00:00:00

abstract：:Concerning molecular and cellular mechanisms of aluminum toxicity, recent studies support the hypothesis that interactions of aluminum ions with elements of signal transduction pathways are apparently primary events in cells. In the case of the phosphoinositide-associated signalling pathway of neuroblastoma cells, gua...

journal_title：Archives of toxicology

authors： Haug A,Shi B,Vitorello V

更新日期：1994-01-01 00:00:00

abstract：:The release and availability of the carcinogenic component of the soluble azo dye Direct Red 46 and the insoluble azo pigment Pigment Yellow 17 were analyzed in Wistar rats using hemoglobin adducts as a dosimeter. The levels of hemoglobin adducts were found to be very low. Intestinal cleavage and release of 3,3'-dichl...

journal_title：Archives of toxicology

authors： Zwirner-Baier I,Neumann HG

更新日期：1994-01-01 00:00:00

abstract：:Capillary gas chromatography coupled to mass spectrometry was employed to quantify ethylmorphine in biological fluids and tissues in a death attributed to oral ethylmorphine ingestion. The femoral blood concentration of the drug was 488 ng/ml. Hair analysis revealed the individual's drug abuse pattern, particularly th...

journal_title：Archives of toxicology

authors： Kintz P,Jamey C,Mangin P

更新日期：1994-01-01 00:00:00

abstract：:Inhalation exposure to toluene diisocyanate (TDI) can result in a variety of airway diseases. Concern has been expressed that a putative carcinogenic potential of TDI exists as a result of the formation of toluenediamine (TDA) by hydrolysis of the isocyanate in the body. Results from long-term bioassays (TDI inhalatio...

journal_title：Archives of toxicology

authors： Kennedy AL,Wilson TR,Stock MF,Alarie Y,Brown WE

更新日期：1994-01-01 00:00:00

abstract：:A wide variety of immunosuppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in experimental animals has been documented. In contrast, the impact of dioxin on the human immune system remains controversial, although adverse health effects have been reported in humans after occupational or accidental exposu...

journal_title：Archives of toxicology

authors： Lang DS,Becker S,Clark GC,Devlin RB,Koren HS

更新日期：1994-01-01 00:00:00

abstract：:The effects of a single dose of ethanol on the metabolism and toxicity of chloroform administered to rats per os (p.o.), intraperitoneally (i.p.), or by inhalation (inh) at different doses were investigated. Rats that had been given either ethanol (2 g/kg) or vehicle (water) alone at 4 p.m. on the previous day were ch...

journal_title：Archives of toxicology

authors： Wang PY,Kaneko T,Tsukada H,Sato A

更新日期：1994-01-01 00:00:00

abstract：:Effects of the oxime HI-6, unrelated to reactivation of acetylcholinesterase (AChE), on field potentials in the dentate gyrus of the rat hippocampus following AChE inhibition, were investigated both in vitro and in vivo. In hippocampal slices, AChE inhibition decreased the perforant path evoked population spike amplit...

journal_title：Archives of toxicology

authors： Melchers BP,van der Laaken AL,Busker RW,Bruijnzeel PL,Van Helden HP

更新日期：1994-01-01 00:00:00

abstract：:3-(Phenylamino)alanine (PAA), a contaminant found in L-tryptophan tablets, has been discussed as a possible cause of eosinophilia-myalgia syndrome (EMS). We administered PAA (100 mg/kg) by gastric gavage to Wistar rats to determine its distribution and metabolism. We developed a purification procedure, using Bond Elut...

journal_title：Archives of toxicology

authors： Adachi J,Mio T,Ueno Y,Naito T,Nishimura A,Fujiwara S,Sumino K,Tatsuno Y

更新日期：1994-01-01 00:00:00

abstract：:Platinum coordination complexes (PtCx) are potent against several types of cancer but are often nephrotoxic. With a view to developing a PtCx nephrotoxicity model, the toxicity of cisplatin (cDDP), transplatin (tDDP) and carboplatin (CBDCA) was studied in primary cultures of rabbit proximal tubule (RPT) cells and in t...

journal_title：Archives of toxicology

authors： Courjault F,Leroy D,Coquery L,Toutain H

更新日期：1993-01-01 00:00:00

abstract：:Previous human and experimental studies have demonstrated that lead exposure may modify the metabolism of lipids. Several studies have indicated that exposure to lead produces an increase in lipid peroxidation and inhibits blood superoxide dismutase activity. Recently, lipid peroxides have been shown to impair tissue ...

journal_title：Archives of toxicology

authors： Skoczyńska A,Smolik R,Jeleń M

更新日期：1993-01-01 00:00:00

abstract：:To explain the mechanism of renal injury caused by liver ischemia-reperfusion, we investigated biochemical and morphological changes in the liver and kidney in rats. After reperfusion following 60 min of liver ischemia, numerous changes were found. The level of serum transaminases and lipid peroxide formation in the l...

journal_title：Archives of toxicology

authors： Kudo Y,Egashira T,Takayama F,Yamanaka Y,Shimada T

更新日期：1993-01-01 00:00:00

abstract：:Free radical processes are proposed to play a crucial role in the development of procainamide adverse effects. Therefore, selenium, as a potent antioxidant, may modified procainamide toxicity. To test this hypothesis plasma and liver thiobarbituric acid-reacting substances (TBARS), plasma antioxidant activity (AOA), e...

journal_title：Archives of toxicology

authors： Toborek M,Magner-Wróbel K,Drózdz M,Danch A,Kopieczna-Grzebieniak E

更新日期：1993-01-01 00:00:00

abstract：:The effect of various hepatotoxicants on urinary taurine and urinary creatine has been studied in the rat. Several hepatotoxic agents, carbon tetrachloride, thioacetamide, galactosamine and allyl alcohol which all caused hepatic necrosis (sometimes accompanied by steatosis), resulted in a rise in urinary taurine and i...

journal_title：Archives of toxicology

authors： Waterfield CJ,Turton JA,Scales MD,Timbrell JA

更新日期：1993-01-01 00:00:00

abstract：:The nephrotoxic action of aristolochic acid (AA) was investigated in female Wistar rats given single doses of 10, 50 or 100 mg/kg by gastric tube. Renal lesions developed within 3 days, the effect being dose-dependent. Histologically, there was evidence of necrosis of the epithelium of the renal tubules, and functiona...

journal_title：Archives of toxicology

authors： Mengs U,Stotzem CD

更新日期：1993-01-01 00:00:00